The history of the Big South in NCAA Tournament Play-in/”First Four” games:

1991: Coastal Carolina beat Jackson State 84-53
2001: Winthrop lost to Northwestern State 71-67
2003: UNC-Asheville beat Texas Southern 92-84 in overtime
2010: Winthrop lost to Arkansas-Pine Bluff 61-44
2011: UNC-Asheville beat Arkansas-Little Rock 81-77 in overtime

Big South teams are 3-2 all-time. The 3 winners all went on to lose their next game in the tournament.